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Quick overview


Zinc is considered the “Universal Soldier”; implicating that zinc is involved in numerous diseases and health problems. Zinc is required for gene expression and protein synthesis and is an integral part of nearly 200 metalloenzymes. Thus, it is clear that zinc is vital in our lives although its effect is not immediate and often neglected because people are unaware of the fact that it plays a critical role in maintaining our health. It is also equally important to know that zinc metabolic cycle is only five hours and most of the metabolized zinc is excreted back through the small and large intestines. In the zinc deficient state, zinc excretion is minimal and tends to reduce cellular functions and growth. Based on these facts it is recommended to take zinc capsule four times a day for patients with zinc-malabsorption syndromes or once or twice for maintaining normal health. Specially, the older population should supplement zinc because in old age, one can develop zinc deficiency due to the decreased ability of intestinal zinc absorption and cellular zinc metabolism. Children and teenagers also need sufficient amount of zinc in their bodies for optimal growth and development.

What is Pro-Z™ 
After the realization of importance of zinc in human health and diseases about three decades ago, many health care specialists and scientists have been investigating to elucidate the mechanisms of intestinal zinc absorption by which adequate zinc nutriture can be maintained for those with genetic and acquired intestinal zinc malabsorption syndromes. Although numerous factors involved in the regulation of intestinal zinc absorption have been identified, the exact mechanisms have not yet been established. We have recently identified and characterized that animal prostate substance is a powerful intestinal zinc absorption stimulator. Pro-Z™ is an amino acid supplement made of natural substances, such as the animal prostate substance and amino acid chelated zinc. Animal studies and clinical trials have shown that oral administration of prostate substance significantly increased intestinal zinc absorption and lowered both blood glucose levels and intake of water and food. 2 

How does it work? 
Pro-Z™ is an ideal formula for zinc metabolism and intestinal zinc absorption since it consists of multiple biochemical agents known to stimulate these crucial mechanisms. Especially, impaired glucose metabolism is closely related to the conditions of zinc deficiency. Impaired glucose metabolism is mainly caused by protein peptide build-ups, which have not been broken down in the cells. Once zinc is properly absorbed into the cells, it activates the synthesis of the insulin degrading enzymes (IDE), which cannot be formed in the state of zinc deficiency. Subsequently, the insulin degrading enzymes digest the fragments of protein peptides, promoting effective insulin transportation. In this case, Pro-Z™ plays a role of supplying zinc into the cells to enhance the synthesis of more insulin Degrading Enzyme (IDE), which is a zinc enzyme. During the last three decades, several biochemical agents were found to be involved in the regulation of intestinal zinc absorption associated with blood glucose lowering activities. Interestingly, the prostate is the organ that contains the highest amounts of zinc and these biochemical agents known to regulate intestinal zinc absorption and cellular zinc uptake. These constituents in Pro-Z™ listed below act synergistically to enhance intestinal zinc absorption and improve impaired glucose metabolism: l Prostaglandins l Arachidonic acid l L-histidine l Testosterone l Citric acid l Cyclo-(His-pro)2 

Why Pro-Z™ instead of Zinc tablets which are much cheaper choice of dietary supplement for Zinc nutrition than Pro-Z™? 
Zinc absorption mechanisms are complex and many factors are involved in the control intestinal Zinc absorption and cellular Zinc metabolism. Just as calcium intake alone is not effective to meet the calcium requirement for human body without Vitamin D supplementation, or body function to produce active Vitamin D for calcium absorption, stimulation of Zinc absorption requires several factors such as Prostaglandin, Arachidonic Acid, Cyclo (His-Pro), and other Zinc metabolism regulating agents. Prostate substance contains all or many of these constituents. In addition, Pro-Z™ is made of soft gel capsules, which is opened in the small intestine, where Zinc is absorbed without binding to gastric mucosal cells. Common zinc tablets melt in the stomach and bind to the gastric mucosal cells, irritating the stomach where it is not absorbed. Furthermore, if Zinc is bound to food chemicals such as fiber and Phytic acid, Zinc is not absorbed at all. Zinc plays a key role in insulin production and uptake of glucose into the muscle and fat cells. Although zinc supplement may be taken alone to supply zinc into the body, there would be no significant effects on correcting zinc deficiency unless proper zinc metabolism and intestinal zinc absorption take place. Studies have shown that merely high doses of zinc supplementations were minimally effective in stimulating sufficient zinc metabolism and intestinal zinc absorption, These studies suggest that stimulation of zinc metabolism and the effectiveness of intestinal absorption are important in the improvement of diseases and disorder associated with zinc deficiency. Pro-Z™ is formulated with biochemical agents best known for these mechanisms and will effective supply chelated zinc to the body’s cells.

Development of studies leading toward the discovery of Pro-Z™ 
The research staffs at the UCLA School of Medicine and VA Greater Los Angeles Healthcare System first developed a nutraceutical which improves impaired glucose metabolism and enhances intestinal zinc absorption, which they obtained patent approval in the USA and many other countries in Europe and in Asia. The effectiveness of this formula on patients with zinc deficiency due to impaired glucose metabolism has been scientifically approved by clinical trials.


Are there test results from clinical trials to prove the effectiveness or safety of Pro-Z™? 
Clinical trials have been initiated at the VA Greater Los Angeles Health Care System involving 40 diabetic patients for a period of 16 months. Hemoglobin A1C test results indicated that the patients’ HbA1C levels reduced from 8.5% to 6.7%. 

Zinc: What is it?
Almost all of the cells in our body contain zinc, an essential mineral which stimulates the activity of about 100 enzymes that are needed for promoting the biochemical reactions in our bodies. 


How can zinc deficiency affect us?
Zinc is vital in our lives. Zinc is required for the function of many intracellular proteins, including enzymes, transcription factors and proteins involved in DNA replication. Zinc deficiency most often occurs when zinc intake is inadequate or poorly absorbed, when there are increased losses of zinc from the body, or when the body's requirement for zinc increases. Zinc deficiency is a condition commonly associated with numerous diseases and disorders including:


  • Skin disorders
  • Cirrhosis of the liver
  • Diabetes/ hyperglycemia
  • Chronic infections
  • Retardation of skeletal muscle maturation
  • Impotency
  • Immunological system disorder

Patients with Zinc deficiency syndromes can significantly benefit from proper zinc supplementation.

The immune system
Since zinc is required for immunoglobulin synthesis, zinc supplementation shortens the duration of cold illnesses (shorten from 10 days to 3 days) and decreases or prevents catching of cold viruses. It is also helpful in fighting against other infectious diseases such as hepatitis

Growth retardation
Growing children require more zinc than adults because zinc is required for cell growth. Especially the underdeveloped children are affected mostly from inadequate dietary intake and impaired intestinal zinc absorption. Growth retardation is a typical clinical feature of zinc deficiency. Particularly, infants born small during gestation age have more weight gain and linear growth during the first 6 months of life, when they received zinc supplementation. Genetically affected children such as with Down syndrome, sickle cell anemia, Acrodermatitis enteropathica can accelerate growth by supplementation of zinc.

Zinc deficiency is prevalent among aging population, because many experience metabolic abnormalities (
metabolic syndrome X) since zinc metalloenzymes and zinc proteins play important roles in many aspects of cellular metabolism including DNA replication, repair and transcription. Zinc supplementation increases the speed of immune response in the aged group. Thus, adequate zinc nutrition can be extremely beneficial for the elderly in prolonging healthy life span.


Obesity is the result of an imbalance between food intake and energy expenditure, mostly due to leptin resistance. Zinc stimulates leptin production in humans which reduces appetite.

Zinc is involved in numerous physiochemical activities related to glucose metabolism. Diabetic animals and humans are zinc-deficient due to hyperzincuria and impaired intestinal zinc absorption. Epidemiological studies have indicated that prevalence of diabetes and impaired glucose tolerance is significantly higher among subject with insufficient zinc nutrition.

Zinc and insulin interaction
Zinc is a cofactor for the gene expression, and synthesis, storage and secretion of insulin. Zinc deficiency induces diminished insulin synthesis. Decreased plasma zinc impairs the ability of the islet cells to produce and secrete insulin and stabilizing insulin, and zinc deficiency resulted in rapid insulin degradation.8, There is a positive correlation between urinary zinc excretion and increased blood hemoglobin A1c levels. Impaired intestinal zinc absorption is associated with hyperglycemia or diabetes.


Zinc has an insulin-like effect on cells, including promotion of both lipogenesis and glucose transport
1. Zinc stimulates tyrosine autophosphorylation of the insulin receptor -subunit of both preadipocytes and adipocytes.
2. Zinc induces glucose transport into cells and potentiate insulin-induced glucose transport, via activation of insulin signaling pathways. Promotion of glucose transport into target cells modulates blood glucose concentrations, and failure to enhance glucose transport into insulin-sensitive cells is a hall mark of diabetes.
3. Zinc deficiency affects function of the insulin-signaling pathway.1, 
4. Zinc is involved in gene expression for GLUT4 synthesis.

Significance of zinc on insulin degrading enzyme (IDE)
Zinc is an integral part of insulin degrading enzyme (IDE), aminopeptidase and endopeptidase. Impaired synthesis of these enzymes induces insulin resistance. Incomplete digestion of internalize insulin and other used proteins results in impaired insulin-receptor mediated signal transduction process in regulating glucose uptake. Zinc is an integral part of IDE and is essential for its activity for preventing insulin resistance and diabetes.

What is the RDA (Recommended dietary allowance) for zinc?
Table 1: Recommended Dietary Allowances for Zinc for Infants over 7 months, Children, and Adults



Infants and Children





7 months to 3 years

3 mg


4 to 8 years

5 mg


9 to 13 years

8 mg


14 to 18 years


11 mg

9 mg

13 mg

14 mg



11 mg

8 mg

11 mg

12 mg

Results of two national surveys, the National Health and Nutrition Examination Survey (NHANES III 1988-91) (12) and the Continuing Survey of Food Intakes of Individuals (1994 CSFII) (13) indicated that most infants, children, and adults consume recommended amounts of zinc.

What food sources provide zinc?
Although most young people who consume adequate protein and essential fatty acids do not have a problem to maintain adequate Zinc nutrition, population with aging, afflicted with diseases such as diabetes, obesity, sickle cell anemia, skin disorders, etc., and those whose main food sources are vegetable or plants are prone not to have adequate Zinc absorption. Therefore, people who are normally vegetarians exhibit growth retardations and weakness, and are susceptible to diseases such as common cold, infectious diseases and other undernourished symptoms. However, overeating without exercise causes problems of obesity, diabetes, heart attack, and cancer etc., and affect Zinc metabolism. Therefore, aging populations and growing young populations most likely need Zinc supplements.
Some food sources that contain zinc include: red meat, poultry, fortified breakfast cereal, some seafood, whole grains, dry beans, and nuts.

Take Pro-Z ™ for stimulating proper zinc absorption
Although zinc supplement may be taken alone to supply zinc into the body, there would be no significant effects on promoting proper zinc metabolism and intestinal zinc absorption in disease states such as aging, diabetes, obesity, and other genetic abnormalities including Acrodermatitis eneteropathica. Prostate substance + Zinc taken together serve as an excellent formula for promoting effective zinc metabolism.


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